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Purpose
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A potent and selective B-Raf inhibitor
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Characteristics
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B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC₅₀s of 0.31 µM and 2 nM for A375 proliferation and A375 p-ERK respectively. PubChem CID: 44223999
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Purity
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> 98 % by HPLC
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Chemical Name
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N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]- 1,5-Isoquinolinediamine
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Formula
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C₂₆H₁₉ClN₈
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Permeability
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Cell-permeable
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Solubility
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DMSO
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