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Purpose
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A sub-nanomolar potent mTOR inhibitor
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Characteristics
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A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.19 nM). Displays >5000-fold selectivity over PI3Ks. WYE-132 inhibits mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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1-{4-[1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-3-methyl-urea; WYE-125132
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Formula
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C₂₇H₃₃N₇O
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Permeability
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Cell-permeable
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Solubility
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DMSO (50 mg/mL)
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