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  • 产品名称：CRTInhibitor,iCRT5

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  • 产品厂商：Biovision
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简单介绍：
CRTInhibitor,iCRT5
详情介绍：
Purpose A β-catenin-responsive transcription (CRT) inhibitor
Characteristics A potent inhibitor of the beta-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an IC50 of 18 nM. It acts by disrupting the interaction between beta-catenin and TCF4, possibly by direct binding to beta-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.
Purity ≥ 98 % by HPLC
Chemical Name (Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid
Formula C₁₆H₁₇NO₅S₂
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 367.44 g/mol
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months
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image for CRT Inhibitor, iCRT5 (ABIN629271) CRT Inhibitor, iCRT5