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  • 产品名称：Bufalin

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  • 产品厂商：Biovision
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简单介绍：
Bufalin
详情介绍：
Purpose Acts as a specific Na/K-ATPase inhibitor.
Characteristics White to off-white solid
Molecular formular: C24H34O4
Purity ≥ 98 % by HPLC
Chemical Name 3β,14-Dihydroxy-5β,20(22)-bufadienolide, 5β,20(22)-Bufadienolide-3β,14-diol
Formula C₂₄H₃₄O₄
Permeability Cell-permeable
Molecular Weight 386.52 g/mol
CAS-No 465-21-4
Comment

Synonyms:
3,14-Dihydroxy-5,20(22)-bufadienolide, 5,20(22)-Bufadienolide-3,14-diol
Bufalin is cardioactive steroid that exhibits a variety of biological activities, such as cardiotonic, anaesthetic, blood pressure stimulatory, respiratory and antineoplastic effects. Acts as a specific Na/K-ATPase inhibitor. More potent than ouabain. Induces cell differentiation. Induces apoptosis in U937 and HL-60 cells by activation of AP-1 via a MAPK pathway that involves JNK. Regulates Tiam1 gene. Down regulates expression of 14-3-3 protein
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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image for Bufalin (ABIN1889124) Bufalin