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  • 产品名称：WntAntagonist,C59

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  • 产品厂商：Biovision
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WntAntagonist,C59
详情介绍：
Characteristics Cell-permeable. A potent Wnt signaling pathway inhibitor (IC50 = < 0.11 nM using Wnt-Luc reporter assay).
Synonyms: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl)acetamide
Purity ≥ 97 % by HPLC
Chemical Name 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl)acetamide
Formula C₂₅H₂₁N₃O
Permeability Cell-permeable
Molecular Weight 379.45 g/mol
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for Wnt Antagonist, C59 (ABIN1304020) Wnt Antagonist, C59
Product cited in: Chevillard-Briet, Quaranta, Grézy, Mattera, Courilleau, Philippe, Mercier, Corpet, Lough, Ueda, Fukunaga, Trouche, Escaffit: "Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling." in: Human molecular genetics, Vol. 23, Issue 8, pp. 2120-31, 2014 (PubMed).

Proffitt, Madan, Ke, Pendharkar, Ding, Lee, Hannoush, Virshup: "Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer." in: Cancer research, Vol. 73, Issue 2, pp. 502-7, 2013 (PubMed).