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Purpose
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A cell-permeable inhibitor of calpain I, calpain II, cathepsin B, and cathepsin L
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Brand
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EZSolution™
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Sequence
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Ac-Leu-Leu-Nile-CHO
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Characteristics
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A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase
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Purity
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≥ 95 % by HPLC
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Chemical Name
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Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al
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Formula
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C₂₀H₃₇N₃O₄
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Permeability
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Cell-permeable
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Solubility
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anhydrous ethanol
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