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  • 产品名称：Canertinib(CI-1033,PD-183805)

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  • 产品厂商：Biovision
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Canertinib(CI-1033,PD-183805)
详情介绍：
Characteristics Canertinib is an irreversible tyrosine kinase inhibitor.It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules. Canertinib alkylates a cysteine residue specific to ErbB receptors. The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms.
Purity ≥ 99 %
Chemical Name CI-1033, PD-183805, PD 183805
Formula C₂₄H₂₅ClFN₅O₃ . 2HCl
Permeability Cell-permeable
Molecular Weight 558.86 g/mol
CAS-No 289499-45-2
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
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image for Canertinib (CI-1033, PD-183805) (ABIN412218) Canertinib (CI-1033, PD-183805)
Product cited in: Gessain, Tsai, Travier, Bonazzi, Grayo, Cossart, Charlier, Disson, Lecuit: "PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenes." in: The Journal of experimental medicine, Vol. 212, Issue 2, pp. 165-83, 2015 (PubMed).