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  • 产品名称：Lactacystin(Synthetic)

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  • 产品厂商：Biovision
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Lactacystin(Synthetic)
详情介绍：
Characteristics Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic beta-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC50 = 10 µM).
Purity ≥ 95 % by HPLC
Chemical Name 2-(acetylamino)-3-[({3-hydroxy-2-[1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)sulfanyl]propanoic acid
Formula C₁₅H₂₄N₂O₇S
Permeability Cell-permeable
Molecular Weight 376.42 g/mol
CAS-No 133343-34-7
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
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image for Lactacystin (Synthetic) (ABIN412313) Lactacystin (Synthetic)
Product cited in: Verma, Marchese: "The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR." in: The Journal of biological chemistry, Vol. 290, Issue 11, pp. 6810-24, 2015 (PubMed).