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  • 产品名称：ActinomycinD(10mM)

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  • 产品厂商：Biovision
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简单介绍：
ActinomycinD(10mM)
详情介绍：
Purity > 98 % by TLC
Chemical Name Actinomycin C1, Actinomycin IV, Dactinomycin
Formula C₆₂H₈₆N₁₂O₁₆
Permeability Not-permeable
Molecular Weight 1255.5 g/mol
CAS-No 50-76-0
Application Notes We recommend using 1000X dilutions for inducing apoptosis in Jurkat cells (e.g., Add 1 µL to 1 mL of culture medium).
However the optimal doses may vary for different cells and culture conditions.
Comment

An antineoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells. A potent inducer of apoptosis in many cell lines (1).
Restrictions For Research Use only
Format Liquid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 6 months
Supplier Images
image for Actinomycin D (10 mM) (ABIN412354) Actinomycin D (10 mM)
Product cited in: Goplen, Bougnaud, Rajcevic, Bøe, Skaftnesmo, Voges, Enger, Wang, Tysnes, Laerum, Niclou, Bjerkvig: "αB-crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells." in: The American journal of pathology, Vol. 177, Issue 4, pp. 1618-28, 2010 (PubMed).