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  • 产品名称：G418Sulfate

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  • 产品厂商：Biovision
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简单介绍：
G418Sulfate
详情介绍：
Characteristics PubChem CID: 16760463
Molecular Formula: C₂₀H₄₀N₄O₁₀. 2 H₂SO₄
Cell Premeable: No
Aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3,Ä≤-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.
Purity > 720 U/mg (potency)
Chemical Name Antibiotic G418, G418
Formula C₂₀H₄₀N₄O₁₀. 2 H₂SO₄
Permeability Not-permeable
Background Synonyms: Antibiotic G418, G418
Molecular Weight 692.71 g/mol
CAS-No 108321-42-2
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for G418 Sulfate (ABIN412125) G418 Sulfate
Product cited in: Lehman, Montford, Horita, Ostriker, Weiser-Evans, Nemenoff, Furgeson: "Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells." in: Molecular pharmacology, Vol. 86, Issue 5, pp. 570-9, 2014 (PubMed).

Tian, Wang, Xu, Guo, Wang, Sun, Liu, Cui, Zhuang, Bao, Schley, Chung, Laslett, Willam, Qin, Maxwell, Esteban: "The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity." in: The Journal of biological chemistry, Vol. 289, Issue 6, pp. 3339-51, 2014 (PubMed).