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  • 产品名称：JC-1

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  • 产品厂商：Biovision
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JC-1
详情介绍：
Characteristics JC-1 is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. JC-1 monomer is in equilibrium with so called J-aggregates, which are favored at higher mitochondrial membrane potential. The monomer JC-1 has green fluorescence (lem = 527 nm), while the J-aggregates have red fluorescence (lem = 590 nm). Therefore, it has been possible to use fluorescence ratioing technique to study mitochondrial membrane potential. JC-1 is particularly useful for apoptosis studies. In apoptotic cells, the dye stays in the cytoplasm and fluoresces green, while in healthy cells, the dye aggregates in the mitochondria and fluoresces red.
Purity > 98 % by HPLC
Chemical Name 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-benzimidazolylcarbocyanine Iodide
Formula C₂₅H₂₇Cl₄IN₄
Permeability Cell-permeable
Molecular Weight 652.23 g/mol
CAS-No 3520-43-2
Application Notes JC-1 is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. JC-1 monomer is in equilibrium with so called J-aggregates, which are favored at higher mitochondrial membrane potential. The monomer JC-1 has green fluorescence (lambda Em = 527 nm), while the J-aggregates have red fluorescence (lambda Em = 590 nm). Therefore, it has been possible to use fluorescence ratioing technique to study mitochondrial membrane potential. JC-1 is particularly useful for apoptosis studies. In apoptotic cells, the dye stays in the cytoplasm and fluoresces green, while in healthy cells, the dye aggregates in the mitochondria and fluoresces red.
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 12 months
Supplier Images
image for JC-1 (ABIN412068) JC-1
Product cited in: Hung, Chan, Chu, Tsai: "Docetaxel Facilitates Endothelial Dysfunction through Oxidative Stress via Modulation of Protein Kinase C Beta: The Protective Effects of Sotrastaurin." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 145, Issue 1, pp. 59-67, 2015 (PubMed).

Trondl, Flocke, Kowol, Heffeter, Jungwirth, Mair, Steinborn, Enyedy, Jakupec, Berger, Keppler: "Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells." in: Molecular pharmacology, Vol. 85, Issue 3, pp. 451-9, 2014 (PubMed).

Chen, Sheu, Liao, Tsai, Kao, Su: "Taiwanofungus camphoratus (Syn Antrodia camphorata) extract and amphotericin B exert adjuvant effects via mitochondrial apoptotic pathway." in: Integrative cancer therapies, Vol. 12, Issue 2, pp. 153-64, 2013 (PubMed).

Lin, Hsiao, Shih, Chou, Sheu: "Mechanisms of resveratrol-induced platelet apoptosis." in: Cardiovascular research, Vol. 83, Issue 3, pp. 575-85, 2009 (PubMed).

Wang, Yang, Su, Xiao, Wang, Li, Lin, Fenton, Paoni, Ding, Keng, Okunieff, Zhang: "Enhanced antitumor effect of combined triptolide and ionizing radiation." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 16, pp. 4891-9, 2007 (PubMed).

Otake, Mims, Fernandes: "Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix." in: Molecular pharmacology, Vol. 69, Issue 4, pp. 1477-85, 2006 (PubMed).