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  • 产品名称：PD-0325901

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  • 产品厂商：Biovision
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简单介绍：
PD-0325901
详情介绍：
Characteristics A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.
Purity ≥ 95 % by HPLC
Chemical Name N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide
Formula C₁₆H₁₄F₃IN₂O₄
Permeability Cell-permeable
Molecular Weight 482.2 g/mol
CAS-No 391210-10-9
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
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image for PD-0325901 (ABIN412237) PD-0325901
Product cited in: Abujarour, Bennett, Valamehr, Lee, Robinson, Robbins, Le, Lai, Flynn: "Myogenic differentiation of muscular dystrophy-specific induced pluripotent stem cells for use in drug discovery." in: Stem cells translational medicine, Vol. 3, Issue 2, pp. 149-60, 2014 (PubMed).