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  • 产品名称：ATMKinaseInhibitor,KU-55933

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  • 产品厂商：Biovision
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简单介绍：
ATMKinaseInhibitor,KU-55933
详情介绍：
Purpose An ATM kinase inhibitor
Characteristics A potent, selective and ATP-competitive inhibitor of Atm Kinase (Ki = 2.2 nM, IC50 = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC50 = 2500, 9300, 16600, >100000 and >100000 nM, respectively).
Purity ≥ 97 % by HPLC
Chemical Name 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933
Formula C₂₁H₁₇NO₃S₂
Permeability Cell-permeable
Solubility DMSO (100 mM) and Ethanol (50 mM)
Molecular Weight 395.49 g/mol
CAS-No 587871-26-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for ATM Kinase Inhibitor, KU-55933 (ABIN412287) ATM Kinase Inhibitor, KU-55933
Product cited in: DeLoughery, Luczak, Ortega-Atienza, Zhitkovich: "DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 143, Issue 1, pp. 54-63, 2014 (PubMed).