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  • 产品名称：SCD1Inhibitor

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  • 产品厂商：Biovision
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SCD1Inhibitor
详情介绍：
Purpose A SCD1(stearoyl-CoA desaturase 1 inhibitor
Characteristics A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1, <4 4="" nm="" for="" mscd1).="" also="" exhibited="" in="" vivo="" efficacy="" with="" dose-dependent="" desaturation="" index="" lowering="" effect.="" scd1="" inhibition="" resulted="" alterations="" macrophage="" membrane="" lipid="" composition="" and="" marked="" hypersensitivity="" to="" toll-like="" receptor="" agonists.="" <="" td="">
Purity ≥ 95 % by HPLC
Chemical Name 4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide
Formula C₂₀H₂₂ClN₃O₃
Permeability Cell-permeable
Solubility DMSO (~ 180 mg/ml)
Molecular Weight 387.86 g/mol
CAS-No 1032229-33-6
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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image for SCD1 Inhibitor (ABIN412321) SCD1 Inhibitor
Product cited in: Iwasaki, Suganami, Hachiya, Shirakawa, Kim-Saijo, Tanaka, Hamaguchi, Takai-Igarashi, Nakai, Miyamoto, Ogawa: "Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages." in: Diabetes, Vol. 63, Issue 1, pp. 152-61, 2013 (PubMed).