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  • 产品名称：HuwentoxinXVI

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  • 产品厂商：Smartox-Biotech
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简单介绍：
HuwentoxinXVI
详情介绍：
Sequence AA sequence: Cys1-Ile-Gly-Glu-Gly-Val-Pro-Cys8-Asp-Glu -Asn-Asp-Pro-Arg-Cys15-Cys16-Ser-Gly-Leu- Val-Cys21-Leu-Lys-Pro-Thr-Leu-His-Gly-Ile-Trp -Tyr-Lys-Ser-Tyr-Tyr-Cys36-Tyr-Lys-Lys-OH Disulfide bonds: Cys1-Cys16, Cys8-Cys21 and Cys15-Cys36
Characteristics Huwentoxin XVI blocks Cav2.2
Background Huwentoxin-XVI is a 39 amino acids peptide that was discovered from the venom of the Chinese tarantula Ornithoctonus huwena. Huwentoxin-XVI was shown to be a potent blocker of HVA N-type calcium channels with an IC50 value of 60 nM in rat DRG. The blocking effect appears to be similar to that of ω-conotoxin-GVIA and ω-conotoxin-MVIIA. Neverthelss, Huwentoxin-XVI differs from GVIA and MVIIA thanks to its greater reversibility and its higher selectivity for N-type over P/Q type than MVIIA.
Molecular Weight 4437.2 kDa
Restrictions For Research Use only
Storage -20 °C