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  • 产品名称:HainantoxinIII

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  • 产品厂商:Smartox-Biotech
  • 产品价格:196.35
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简单介绍:
HainantoxinIII
详情介绍:
Sequence AA sequence: Gly-Cys2-Lys-Gly-Phe-Gly-Asp-Ser-Cys9-Thr -Pro-Gly-Lys-Asn-Glu-Cys16-Cys17-Pro-Asn-Tyr- Ala-Cys22-Ser-Ser-Lys-His-Lys-Trp-Cys-Lys-Val-Tyr-Leu-NH2 Disulfide bonds: Cys2-Cys17, Cys9-Cys22, and Cys16-Cys29
Characteristics Hainantoxin-III specifically blocks mammalian neuronal TTX-S VGSC
Background Hainantoxin-III is a peptide that has been isolated from the venom of the Chinese bird spider Seleconosmia hainana. Hainantoxin-III specifically blocks mammalian neuronal tetrodotoxin-sensitive voltage-gated sodium channels (VGSCs). Hainantoxin III was found inactive on tetrodotoxin-resistant VGSCs and voltage-gated Ca2+ channels (both high and low voltage-activated). Hainantoxin-III strongly depressed the amplitude of rat DRG tetrodotoxin-sensitive Na+ currents with an IC50 value of 1.1 nM. Like Hainantoxin-IV, Hainantoxin-III causes a hyperpolarizing shift of about 10 mV in the voltage midpoint of steady-state Na+ channel inactivation. Similar to Huwentoxin-IV, Hainantoxin-III and -IV do not affect the activation and inactivation kinetics of Na+ currents. Hainantoxin-III inhibits Nav1.7 current amplitude without significantly altering the activation and inactivation kinetics. Hainantoxin-III increases the deactivation of the Nav1.7 current after extreme depolarizations. Hainantoxin-III seems to interact with site 4 and to trap the domain II voltage sensor in the closed state. The inhibition of Nav1.7 by hainantoxin-III is reversible upon washing, but no reversibility was observed for Hainantoxin-IV and Huwentoxin-IV. Hainantoxin-III was shown to block Nav1.1, Nav1.2, Nav1.3 and Nav1.7 expressed in HEK293 cells with IC50 values of 1.27 μM, 275 nM, 491 nM and 232 nM, respectively.
Molecular Weight 3608.20 kDa
Restrictions For Research Use only
Storage -20 °C