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  • 产品名称:GsAF-II

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  • 产品厂商:Smartox-Biotech
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简单介绍:
GsAF-II
详情介绍:
Purpose GsAF-II is a VGSC blocker
Sequence Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Glu-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Leu-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Ile-Glu-Trp-OH(Disulfide bonds between Cys2-Cys16, Cys9-Cys21, and Cys15-Cys25)
Background GsAF-II (also termed Kappa-theraphotoxin-Gr2c) was originally isolated from the venom of Grammostola rosea spider. This peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM.
Molecular Weight 3979.78 Da
Restrictions For Research Use only