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  • 产品名称：GaTx1

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  • 产品厂商：Smartox-Biotech
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简单介绍：
GaTx1
详情介绍：
Purpose GaTx1 peptide is a CFTR blocker
Sequence Cys-Gly-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Glu-Gln-Lys-Cys-Ala-Glu-Cys-Cys-Gly-Gly-Ile-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Asn-Arg-NH2(Disulfide bonds between Cys1-Cys18, Cys4-Cys25, and Cys19-Cys32)
Background GaTx1 peptide was originally isolated from the venom of Leiurus quinquestriatus hebraeus. This peptide is a potent and selective inhibitor of CFTR, an anion selective channel belonging to the ABC transporter superfamily. It was shown to block CFTR channels in a state dependent manner by acting from the internal face of the channel and it is supposed to be a non competitive inhibitor of ATP-dependent channel gating. GaTx1 is a valuable tool to explore CFTR structure function.
Molecular Weight 3674.20 Da
Restrictions For Research Use only