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  • 产品名称：GsAF-I

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  • 产品厂商：Smartox-Biotech
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简单介绍：
GsAF-I
详情介绍：
Purpose GsAF-I is a VGSC blocker
Sequence Tyr-Cys2-Gln-Lys-Trp-Leu-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Asp-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Arg-Leu-NH2(Disulfide bonds between Cys2-Cys16, Cys9-Cys21, and Cys15-Cys25)
Background GsAF-I (also termed beta-theraphotoxin-Gr1b) was originally isolated from the venom of Grammostola rosea spider. This peptide toxin is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with respective IC50 values of 0.4, 0.6, 1.3, 0.3, 1.2 and 0.04 µM. In addition, the toxin blocks the hERG1 isoform with an IC50 value of 4.8 µM.
Molecular Weight 3707.48 Da
Restrictions For Research Use only