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  • 产品名称:omega-conotoxinsSO-3(omergacontoxinSO3)

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  • 产品厂商:Smartox-Biotech
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简单介绍:
omega-conotoxinsSO-3(omergacontoxinSO3)
详情介绍:
Purpose omega-conotoxins SO-3 is a calcium channel blocker
Sequence Cys1-Lys-Ala-Ala-Gly-Lys-Pro-Cys8-Ser-Arg-Ile-Ala-Tyr-Asn-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2Disulfide bonds between Cys1-Cys16, Cys8-Cys20and Cys15-Cys25
Background Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). This peptide selectively targets N-type voltage-sensitive calcium channels. It has no effect on R-type calcium currents, voltage-sensitive sodium currents, delayed rectifier potassium currents and transient outward potassium currents. It displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of MVIIA injected intrathecally.
Molecular Weight 2567.07 Da
Restrictions For Research Use only