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  • 产品名称：SNX482

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  • 产品厂商：Smartox-Biotech
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简单介绍：
SNX482
详情介绍：
Purpose SNX482 is a R-Type calcium channel blocker
Sequence Gly-Val-Asp-Lys-Ala-Gly-Cys7-Arg-Tyr-Met-Phe-Gly-Gly-Cys14-Ser-Val-Asn-Asp-Asp-Cys20-Cys21-Pro-Arg-Leu-Gly-Cys26-His-Ser-Leu-Phe-Ser-Tyr-Cys33-Ala-Trp-Asp-Leu-Thr-Phe-Ser-Asp-OHDisulfid e bonds between Cys7-Cys21, Cys14-Cys26 and Cys20-Cys33
Background SNX-482 has been isolated from the venom of the Spider Hysterocrates gigas (African tarantula). This toxin modulates the R-type current associated with the class alpha1E calcium channel (Cav2.3 from the CACNA1E gene). SNX-482 antagonizes channel activation by inducing a depolarizing shift in the activation potential, thus preventing the channel from undergoing normal membrane depolarization. SNX-482acts rapidly and maintains its effect.
Molecular Weight 4496.42 Da
CAS-No 203460-30-4
Restrictions For Research Use only