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  • 产品名称：Waglerin1-FAM

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  • 产品厂商：Smartox-Biotech
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简单介绍：
Waglerin1-FAM
详情介绍：
Sequence AA sequence: FAM-Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys9-His -Pro-Pro-Cys13-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH Disulfide bonds: Cys9-Cys13
Characteristics Waglerin-1-FAM is a nAChR blocker
Background Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler's pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of ***** muscle nicotinic acetylcholine receptors. Waglerin-1 binds selectively to epsilon subunit of nAChR. Some studies have demonstrated that Waglerin-1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons. Some derivatives of Waglerin-1 are currently used in cosmetics to reduce wrinkles. The fluorescent derivative Waglerin-1-FAM can be use to explore the expression and function of the ***** nAChR subtypes.
Molecular Weight 2878.27 kDa
Restrictions For Research Use only
Storage -20 °C
Background publications Teichert, Garcia, Potian, Schmidt, Witzemann, Olivera, McArdle: "Peptide-toxin tools for probing the expression and function of fetal and ***** subtypes of the nicotinic acetylcholine receptor." in: Annals of the New York Academy of Sciences, Vol. 1132, pp. 61-70, 2008 (PubMed).