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  • 产品名称：anti-Swi6antibody

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  • 产品厂商：BioAcademia
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简单介绍：
anti-Swi6antibody
详情介绍：
Characteristics Antiserum
Purification Rabbit serum
Background Swi6 protein of fission yeast is a functional and structural homolog of HP1 (Heterochromatin Protein 1) of animals and is involved in the formation of heterochromatin structure by binding to centromere, telomere and silent mating-type locus. It is also involved in silencing the genes and sister chromatid cohesion by binding to histone H3 methylated at Lys9 and the cohesin subunit Psc3. This antiserum was produced by immunizing full-size Swi6 recombinant protein from E. coli. Although genome data indicate the swi6 gene encodes a protein of 37 kD, Western blot analysis of crude extract of S. pombe detects a protein with an apparent molecular size of 53 kD.
UniProt P40381
Application Notes For the studies of RNAi mechanism:
1. Western blotting: 2,000~10,000 dilution (Backgroud noise should be reduced with diluted antibody)
2. Immunoprecipitation
3. Chromatin Immuno-Precipitation
Restrictions For Research Use only
Format Liquid
Buffer 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Upon receipt aliquot and store at -20 C
Product cited in: Yao, Fuller, Xi: "Programmed DNA deletion as an RNA-guided system of genome defense." in: Science (New York, N.Y.), Vol. 300, Issue 5625, pp. 1581-4, 2003 (PubMed).

Wang, Ma, Chow, Horsley, Brown, Cowell, Singh: "Conservation of heterochromatin protein 1 function." in: Molecular and cellular biology, Vol. 20, Issue 18, pp. 6970-83, 2000 (PubMed).

Ekwall, Javerzat, Lorentz, Schmidt, Cranston, Allshire: "The chromodomain protein Swi6: a key component at fission yeast centromeres." in: Science (New York, N.Y.), Vol. 269, Issue 5229, pp. 1429-31, 1995 (PubMed).