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  • 产品名称：CD160(human):293TLysate

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  • 产品厂商：BioLeaf
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CD160(human):293TLysate
详情介绍：
Characteristics CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol- anchored protein of 181 amino acids with a single Ig- like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. Lysate of human CD160 transfected 293T cells
Alternative Name CD160
Research Area Immunology, Innate Immunity, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes CD160 (h): 293T Lysate is suitable as a Western Blotting positive control for human reactive CD160 antibodies. Recommended use: 10-20 µl per lane. Control 293T Lysate: 293LYS is available as a Western Blotting negative control lysate derived from non-transfected 293T cells.
Restrictions For Research Use only
Handling Advice Repeated freezing and thawing should be minimized. Sample vial should be boiled once prior to use. Non-hazardous. No MSDS required.
Storage -20 °C
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Product cited in: Edwards, Durant, Jones, Evans, Smith: "Differential expression of HLA class II antigens in fetal human spleen: relationship of HLA-DP, DQ, and DR to immunoglobulin expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 137, Issue 2, pp. 490-7, 1986 (PubMed).

Austin, Trowsdale, Rudd, Bodmer, Feldmann, Lamb: "Functional expression of HLA-DP genes transfected into mouse fibroblasts." in: Nature, Vol. 313, Issue 5997, pp. 61-4, 1985 (PubMed).

Royston, Omary, Trowbridge: "Monoclonal antibodies to a human T-cell antigen and Ia-like antigen in the characterization of lymphoid leukemia." in: Transplantation proceedings, Vol. 13, Issue 1 Pt 2, pp. 761-6, 1981 (PubMed).

Background publications Watson, DeMars, Trowbridge, Bach: "Detection of a novel human class II HLA antigen." in: Nature, Vol. 304, Issue 5924, pp. 358-61, 1983 (PubMed).