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Background
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This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
Alias Symbols: PC, APC, PROC1, PROC
Protein Interaction Partner: CSNK2B, TK1, SERPINA5, PROCR, F8, F5, THBD, F2, PROS1, PROC, PF4, SERPINB6, GGCX, CP,
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