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Background
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This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
Alias Symbols: AP-2B, AP2-B, MGC21381
Protein Interaction Partner: YEATS4, UBC, KCTD1, UBE2I, SUMO1, SSBP4, LZTR1, VPS11, HIST1H2AC, CITED4, MYC, CITED2, CITED1,
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