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Background
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The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.
Alias Symbols: HSPG, HSPG1, SYND2, CD362
Protein Interaction Partner: UBC, CSNK2A2, BAG6, SDC2, PPP3CC, SERPINA1, CYP2C18, PRKCG, PRKCB, PRKCA, ELAVL1, TRAPPC4, TNFSF13, SDCBP, EPHB2, LAMA3, TGFBR3, KAL1, CASK, TGFB1, SPARC, PF4, REG3A, NF1, HGF, CSF2, FN1, FGF2, EZR, SERPINC1, CSF2RA, ITPR1, EPB41L1,
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