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Background
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Plays a role in replication-dependent histone mRNA degradation at the end of phase S. Part of a post-splicing multiprotein complex. Involved in nonsense-mediated decay (NMD) as part of the SMG1C complex, a mRNA surveillance complex that recognizes and degrades mRNAs containing premature translation termination codons (PTCs). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, RENT1 is phosphorylated by SMG1, triggering nonsense-mediated decay (NMD). Essential for embryonic viability.
Alias Symbols: FLJ43809, FLJ46894, HUPF1, KIAA0221, NORF1, pNORF1, RENT1, smg-2
Protein Interaction Partner: UBC, SUMO2, STAU1, CDC37, IVNS1ABP, MOV10, DNA2, POP1, LIN28A, UPF3B, STAU2, UPF2, EZH2, BMI1, SUZ12, RNF2, GNPTG, RHOXF2, ACSS2, NADSYN1, PLEKHB2, PLEKHA5, TARDBP, RPRD2, ABHD16A, NDUFB10, DXO, SMG1, RUVBL2, RBM8A, SMG7, EIF4A3, RUVBL1, GSPT2, SMG5, GSPT
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