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Background
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This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Alias Symbols: BAR, B2AR, ADRBR, ADRB2R, BETA2AR
Protein Interaction Partner: ARRDC3, REL, TSHR, TSG101, STAT4, STAT3, SNCG, RGS10, RGS2, RAN, RAB27A, RAB3A, CNN1, CD81, CD68, CD9, CD4, CCKBR, CEACAM1, ARRB2, ARHGDIA, ARHGAP5, HDAC6, GPR56, VAPA, RGS9, RGS11, RGS20, RGS5, VEGFB, VDAC2, VDAC1, KCTD13, ARRDC1, RGS8, SLC52A2, WNK1, RA
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