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Background
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.
Alias Symbols: S14, p31, HIP6, HYPF, Nin1p, Rpn12, MGC1660
Protein Interaction Partner: HUWE1, UBC, PSMD14, TXNL1, PPFIA1, RPS21, RPS12, RPS8, PSMD11, PSMD7, PSMD4, PSMD3, PSMD2, PSMD1, PSMC6, PSMC5, PSMC4, PSMC2, PSMC1, MAP2, DYNC1I2, DHX9, ABCF1, KCMF1, UCHL5, DYNC1LI1, KIAA0368, ADRM1, HNRNPA0, PARK2, RNF11, BAG3, NOS2, SMAD9, SMAD2, PSMD
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