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  • 产品名称:Mouseanti-HumanIgDAntibody

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  • 产品厂商:BioLeaf
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简单介绍:
Mouseanti-HumanIgDAntibody
详情介绍:
Immunogen Human IgD
Clone IA6-2
Isotype IgG2a
Specificity The mouse monoclonal antibody IA6-2 recognizes human immunoglobulin D.
Purification purified.
Background Immunoglobulin D (IgD) is expressed on the surface of naive mature B cells, thus later than IgM, and is coexpressed with it then. Triggered by antigen binding, it signals through the CD79 complex to activate the B cells. Expression of IgD is lost after the isotype switch. Soluble IgD is present in very small amounts in the serum. IgD can bind to basophils and mast cells to activate them in an IgE-independent way to participate in respiratory immune defense.
Research Area Stem Cells, Hematopoietic Progenitors, Secondary Antibodies
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Product cited in: Degauque, Elong Ngono, Ngono, Akl, Lepetit, Crochette, Giral, Lepourry, Pallier, Castagnet, Dugast, Guillot-Gueguen, Jacq-Foucher, Saulquin, Cesbron, Laplaud, Nicot, Brouard, Soulillou: "Characterization of antigen-specific B cells using nominal antigen-coated flow-beads." in: PLoS ONE, Vol. 8, Issue 12, pp. e84273, 2014 (PubMed).

Bunch, McGregor, Khandoobhai, Aybar, Burkart, Hu, Hogan, Poulton, Berg, Falk, Nachman: "Decreased CD5? B cells in active ANCA vasculitis and relapse after rituximab." in: Clinical journal of the American Society of Nephrology : CJASN, Vol. 8, Issue 3, pp. 382-91, 2013 (PubMed).

Di Sabatino, Carsetti, Rosado, Ciccocioppo, Cazzola, Morera, Tinozzi, Tinozzi, Corazza: "Immunoglobulin M memory B cell decrease in inflammatory bowel disease." in: European review for medical and pharmacological sciences, Vol. 8, Issue 5, pp. 199-203, 2005 (PubMed).

Pugh-Bernard, Silverman, Cappione, Villano, Ryan, Insel, Sanz: "Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance." in: The Journal of clinical investigation, Vol. 108, Issue 7, pp. 1061-70, 2001 (PubMed).

Ferrari, Giliani, Insalaco, Al-Ghonaium, Soresina, Loubser, Avanzini, Marconi, Badolato, Ugazio, Levy, Catalan, Durandy, Tbakhi, Notarangelo, Plebani: "Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 22, pp. 12614-9, 2001 (PubMed).

Baier, Baier-Bitterlich, Looney, Altman: "Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro." in: Journal of virology, Vol. 69, Issue 4, pp. 2357-65, 1995 (PubMed).