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  • 产品名称：IRAKDetectionSet

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  • 产品厂商：ProSci-Inc
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简单介绍：
IRAKDetectionSet
详情介绍：
Characteristics Concentrations: Antibody 1 mg/mL, Peptide 200 μg/mL
Purification Antibodies are supplied as affinity chromatography purified IgG.
Components IRAK Antibody, (50 μg)
IRAK-2 (C2) Antibody, (50 μg)
IRAK-M Antibody, (50 μg)
IRAK-4 Antibody, (50 μg)
MyD88 Antibody, (50 μg)
Background Members of the IRAK (IL-1R-associated kinase)/Pelle family play a major role in IL-1R/TLR mediated inflammatory responses and in innate immunity. IRAK and IRAK-2 regulate the activity of a signaling cascade that mediates the activation of NF-κB and MAP kinase. IRAK-4 interacts with and phosphorylates IRAK, while IRAK-M is thought to inhibit the recruitment and activation of IRAK-4 and IRAK. The importance of the IRAK family in inflammation and immunity is illustrated by the fact that animals lacking IRAK-4 are impaired in their responses to viral and bacterial challenges and are completely resistant to LPS challenge.
Application Notes These polyclonal antibodies can be used for detection of various IRAK molecules by Western blot at 2 μg/mL to 1 μg/mL, Immunohistochemistry, and Immunoflourescence. Whole cell lysate from HeLa cells can be used as a positive control for each antibody except IRAK-M antibody and MyD88 antibody, murine spleen lysate should be used as a positive control for IRAK-M antibody and Jurkat whole cell lysate should be used for MyD88 antibody.
Optimal dilutions for each application to be determined by the researcher.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Stable at 4 °C for three months, store at -20 °C for up to one year.
Expiry Date 12 months