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  • 产品名称：TumorNecrosisFactor(Ligand)Superfamily,Member10(TNFSF10)(AA114-281)Peptide

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  • 产品厂商：BioLeaf
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简单介绍：
TumorNecrosisFactor(Ligand)Superfamily,Member10(TNFSF10)(AA114-281)Peptide
详情介绍：
Sequence MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNG ELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWS KDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG
Characteristics Purified recombinant Human TRAIL protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.
Purity > 95 % pure
Endotoxin Level < 1.0 EU per µg of protein (determined by LAL method)
Background TNF-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor (TNF) cytokine family and induces rapid apoptosis in a wide variety of tumor cell lines upon binding to the death-signalling receptors on the cell membrane. TRAIL binds to one of four receptors that have been identified in humans, including TRAIL-R1/DR4, TRAIL-R2/KILLER/DR5, TRAIL-R3/DcR1/TRID, and TRAIL-R4/DcR2/TRUNDD. Both DR4 and DR5 are pro-apoptotic receptors, which contain a cytoplasmic death domain and mediate apoptosis on binding to TRAIL. By contrast, TRID and TRUNDD do not contain a cytoplasmic death domain and block the function of TRAIL by competing with DR4 and DR5 for binding of TRAIL. Recombinant human TRAIL was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: TNFSF10 protein, TRAIL protein, Apo-2 ligand protein, TL2 protein, member 10, Tumor necrosis factor ligand superfamily protein, Tumor necrosis factor (ligand) superfamily protein, CD253 protein, member 10 protein, APO2L protein
Molecular Weight 23 kDa (211 AA)
Research Area Cancer, Apoptosis/Necrosis, Cell Cycle
Application Notes TRAIL protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Supplied as a liquid in 20 mM Tris, pH 7.5, containing 300 mM NaCl, 0.0 mM DTT, and 10 % glycerol.
Preservative Dithiothreitol (DTT)
Precaution of Use This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice Avoid repeated freeze/thaw cycles.
Storage RT/-20 °C
Storage Comment Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
Supplier Images
SDS-PAGE (SDS) image for Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 114-281) peptide (ABIN934957) Figure annotation denotes ug of protein loaded and % gel used.