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  • 产品名称：Mouseanti-Non-HumanPrimateIg(Chainalpha)Antibody

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  • 产品厂商：BioLeaf
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简单介绍：
Mouseanti-Non-HumanPrimateIg(Chainalpha)Antibody
详情介绍：
Immunogen Rat T blasts and erythrocytes
Clone R73
Isotype IgG1
Specificity The mouse monoclonal R73 recognizes TCR alpha/beta, the dominant subtype of T cell receptor expressed in peripheral blood.
Purification Purified from cell culture supernatant by protein-A affinity chromatography.
Purity > 95 % (by SDS-PAGE)
Alternative Name Immunoglobulin Ig
Background The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Product cited in: Fuller, Bogdani, Tupling, Jensen, Pefley, Manavi, Cort, Blankenhorn, Mordes, Lernmark, Kwitek: "Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene." in: Physiological genomics, Vol. 38, Issue 1, pp. 89-97, 2009 (PubMed).

Müller, van den Brandt, Odoardi, Tischner, Herath, Flügel, Reichardt: "A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats." in: The Journal of clinical investigation, Vol. 118, Issue 4, pp. 1405-16, 2008 (PubMed).

Radojevic, Arsenovic-Ranin, Kosec, Pesic, Pilipovic, Perisic, Plecas-Solarovic, Leposavic: "Neonatal castration affects intrathymic kinetics of T-cell differentiation and the spleen T-cell level." in: The Journal of endocrinology, Vol. 192, Issue 3, pp. 669-82, 2007 (PubMed).

Shao, Sun, Kaplan, Sun: "Characterization of rat CD8+ uveitogenic T cells specific for interphotoreceptor retinal-binding protein 1177-1191." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 4, pp. 2849-54, 2004 (PubMed).

Kerstan, Hünig: "Cutting edge: distinct TCR- and CD28-derived signals regulate CD95L, Bcl-xL, and the survival of primary T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 3, pp. 1341-5, 2004 (PubMed).

Li, Thanikachalam, Pang, Kawaharada, Aitouche, Pham: "A clinically relevant CTLA4-Ig-based regimen induces chimerism and tolerance to heart grafts." in: The Annals of thoracic surgery, Vol. 72, Issue 4, pp. 1306-10, 2001 (PubMed).

Carlson, Jansson, Larsson, Bucht, Lorentzen: "The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats." in: The American journal of pathology, Vol. 156, Issue 6, pp. 2057-65, 2000 (PubMed).

Kraus, Lambracht, Wonigeit, Hünig: "Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition." in: European journal of immunology, Vol. 26, Issue 11, pp. 2582-6, 1997 (PubMed).