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  • 产品名称：CASP8andFADD-LikeApoptosisRegulator(CFLAR)(N-Term)Peptide

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  • 产品厂商：PromoCell
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简单介绍：
CASP8andFADD-LikeApoptosisRegulator(CFLAR)(N-Term)Peptide
详情介绍：
Blocked Antibody anti-FLICE Inhibitory Protein (CFLAR) (N-Term) antibody (ABIN1002318)
Characteristics 17 amino amino terminus of human FLIP.
Application Notes FLIP peptide is used for blocking the activity of Anti-FLIP . Incubating the peptide with equal volume of antibody for 30 min at 37ºC usually completely blocks the antibody activity in Western blotting.
Restrictions For Research Use only
Format Liquid
Concentration 200 µg/mL
Buffer Supplied in PBS pH 7.2 (10 mM NaH₂PO₄, 10 mM Na₂HPO₄, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice For products with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. The peptide solution should be gently mixed before use.
Storage -20 °C
Storage Comment Store at -20°C, stable for one year.
Expiry Date 12 months
Product cited in: Gu, Dong, Zhang, McLaughlin, Wu, Schlossman: "Functional interaction of DFF35 and DFF45 with caspase-activated DNA fragmentation nuclease DFF40." in: The Journal of biological chemistry, Vol. 274, Issue 30, pp. 20759-62, 1999 (PubMed).

Background publications Enari, Sakahira, Yokoyama, Okawa, Iwamatsu, Nagata: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, 1998 (PubMed).

Sakahira, Enari, Nagata: "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis." in: Nature, Vol. 391, Issue 6662, pp. 96-9, 1998 (PubMed).

Liu, Zou, Slaughter, Wang: "DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis." in: Cell, Vol. 89, Issue 2, pp. 175-84, 1997 (PubMed).