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  • 产品名称：Mouseanti-HumanIgM(WholeMolecule)Antibody

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简单介绍：
Mouseanti-HumanIgM(WholeMolecule)Antibody
详情介绍：
Immunogen ChromPure Human IgM (myeloma), whole molecule.
Clone 3H10G5F2
Isotype IgG1
Purification Purified
Background Immunoglobulin M (IgM), along with IgA, IgD, and IgE, make up approximately 20 % of the total gamma globulin in the body, with IgG accounting for the other 80 %. Each class of antibody gets its designation from the heavy and light peptide chains that make up the antibody structure. IgM is the first immunoglobulin produced during the immune response and the first antibody produced in neonates. Serum levels of IgM are associated with certain autoimmune diseases, and abnormally low levels may indicate the presence of Wiskott-Aldrich Syndrome, an inherited immunodeficiency disorder. Monoclonal Anti-Human IgM is derived from the hybridoma1 produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Gene ID 83953
Research Area Secondary Antibodies
Application Notes ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Buffer PBS
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Monoclonal antibodies should not be stored at a temperature below -25 °C due to the aggregation effect of the protein.
Storage 4 °C
Product cited in: Klonisch, Panayotou, Edwards, Jackson, Berger, Delves, Lund, Roitt: "Enhancement in antigen binding by a combination of synergy and antibody capture." in: Immunology, Vol. 89, Issue 2, pp. 165-71, 1996 (PubMed).

Background publications Watanabe, Barnikol, Horn, Bertram, Hilschmann et al.: "[The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), II: the amino acid sequence of the H-chain (mu-type), subgroup H III. Architecture of the complete IgM-molecule ..." in: Hoppe-Seyler's Zeitschrift für physiologische Chemie, Vol. 354, Issue 10-11, pp. 1505-9, 1975 (PubMed).