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  • 产品名称：Mouseanti-HumanIgA(Chainalpha)Antibody

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简单介绍：
Mouseanti-HumanIgA(Chainalpha)Antibody
详情介绍：
Immunogen Purified human IgA.
Clone AD3
Isotype IgG1
Specificity The antibody AD3 reacts with alpha-chain of human IgA1 and IgA2.
Purification Purified from ascites by precipitation methods and ion exchange chromatography.
Purity > 95 % (by SDS-PAGE)
Background Immunoglobulin A (IgA) is the major immunoglobulin class in body secretions that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract. Its serum concentration is approximately 0.2 g/l and biological survival (T1/2 in plasma) 6 days. Plasma IgA is predominantly monomeric (160 kDa) and of the IgA1 subclass, and is mostly produced in the bone marrow. Over half of IgA produced by the intestinal lamina propria plasmocytes is in oligomeric form and 35 % of it is IgA2.
Molecular Weight 160 kDa
Research Area Immunology, Secondary Antibodies
Application Notes Immunohistochemistry (paraffin sections) Recommended dilution: 10 µg/mL
Positive tissue: colon

Working concentrations should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 20 mM Tris/HCl with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8 °C. Do not use after expiration date stamped on vial label.
Supplier Images
Immunohistochemistry (IHC) image for Mouse anti-Human IgA (Chain alpha) Antibody (ABIN94396) Immunohistochemistry staining of human colon (paraffin sections) with anti-IgA (clone...
Background publications Jonard, Rambaud, Dive, Vaerman, Galian, Delacroix: "Secretion of immunoglobulins and plasma proteins from the jejunal mucosa. Transport rate and origin of polymeric immunoglobulin A." in: The Journal of clinical investigation, Vol. 74, Issue 2, pp. 525-35, 1984 (PubMed).

Balogh, Merétey, Falus, Bozsóky: "Serological abnormalities in juvenile chronic arthritis: a review of 46 cases." in: Annals of the rheumatic diseases, Vol. 39, Issue 2, pp. 129-34, 1980 (PubMed).

Fuller, Keyser: "Serum immunoglobulins after surgical operation." in: Clinical chemistry, Vol. 21, Issue 6, pp. 667-71, 1975 (PubMed).

Franklin: "Structure and function of immunoglobulins." in: Acta endocrinologica. Supplementum, Vol. 194, pp. 77-95, 1975 (PubMed).