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  • 产品名称：IntegrinAlphaVBeta6(ITGAV/ITGB6)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
IntegrinAlphaVBeta6(ITGAV/ITGB6)(Active)protein(Histag)
详情介绍：
Characteristics Human ITGAV & ITGB6 Heterodimer Protein, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 113 kDa (ITGAV) and 79.6 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 22 (ITGB6). The reducing (R) protein migrates as 145 kDa (ITGAV) and 115 kDa (ITGB6) respectively due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency-associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
Molecular Weight 113 kDa (ITGAV) & 79.6 kDa (ITGB6)
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM NaCl, 2 mM CaCl2
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Integrin AlphaV Beta6 (ITGAV/ITGB6) (Active) protein (His tag) (ABIN2870665) Human ITGAV & ITGB6 Heterodimer Protein on SDS-PAGE under reducing (R) condition. The...
Binding Studies (Bind) image for Integrin AlphaV Beta6 (ITGAV/ITGB6) (Active) protein (His tag) (ABIN2870665) Immobilized Human ITGAVB6, His Tag can bind Human TGF-Beta 1 / TGFB1, His Tag & Avi ...