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  • 产品名称：LowDensityLipoproteinReceptor-RelatedProtein4(LRP4)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
LowDensityLipoproteinReceptor-RelatedProtein4(LRP4)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.7 kDa. The protein migrates as 95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Low-density lipoprotein receptor-related protein 10 (LRP10), a member of the LDLR family, is a single-pass type I membrane protein, which contains two CUB domains and four LDL-receptor class A domains. As a probable receptor, LRP10 is involved in the internalization of lipophilic molecules or signal transduction. LRP10 may be involved in the uptake of lipoprotein APOE in liver. Furthermore, Deletion of the extracellular domain of LRP10 negated its inhibitory effect. It sugested that LRP10 may interfere with the formation of the beta-catenin/TCF complex and its binding to target DNA in the nucleus, and that the extracellular domain of LRP10 is critical for inhibition of the canonical Wnt/beta-catenin signaling pathway. LRP10 has been improved to play a significant role in the brain physiology other than lipoprotein metabolism.
Molecular Weight 72.7 kDa
Pathways Skeletal Muscle Fiber Development
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Low Density Lipoprotein Receptor-Related Protein 4 (LRP4) (Active) protein (Fc Tag) (ABIN2870667) Human LRP-10, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...