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  • 产品名称：TumorNecrosisFactor(Ligand)Superfamily,Member4(TNFSF4)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
TumorNecrosisFactor(Ligand)Superfamily,Member4(TNFSF4)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 42.9 kDa. The protein migrates as 53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
Molecular Weight 42.9 kDa
NCBI Accession NP_003317
UniProt P23510
Pathways Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (Active) protein (Fc Tag) (ABIN2870677) Human OX40 Ligand, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stain...
Binding Studies (Bind) image for Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (Active) protein (Fc Tag) (ABIN2870677) Immobilized Human OX40, His Tag (Cat# OX0-H5224) at 2 μg/mL (100 μl/well) can bind Hu...