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  • 产品名称：ProproteinConvertaseSubtilisin/kexinType9(PCSK9)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
ProproteinConvertaseSubtilisin/kexinType9(PCSK9)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73 kDa. The protein migrates as 18 kDa and 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation and proteolytic digestion.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Molecular Weight 73 kDa
UniProt G3GTK5
Research Area Proteolysis / Ubiquitin, Metabolism, Amino Acids
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (Active) protein (His tag) (ABIN2870601) Hamster PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Binding Studies (Bind) image for Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (Active) protein (His tag) (ABIN2870601) Immobilized Human LDL R (High Purity) Protein, Strep Tag (Cat# LDR-H5281) at 5 μg/mL ...