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  • 产品名称：HepatitisAVirusCellularReceptor2(HAVCR2)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
HepatitisAVirusCellularReceptor2(HAVCR2)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42 kDa. The protein migrates as 45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >97 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Measured by its binding ability in a functional ELISA. Immobilized rhGalectin9 at 500 ng/mL can bind rhHAVCR2-Fc with an apparent KD <30 nm.="" <="" td="">
Background Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
Molecular Weight 42 kDa
UniProt Q8TDQ0
Pathways Regulation of Lipid Metabolism by PPARalpha
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
Supplier Images
SDS-PAGE (SDS) image for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) (Active) protein (Fc Tag) (ABIN2181419) Human TIM-3 (22-142), Fc Tag on SDS-PAGE under reducing (R) condition. The gel was st...
Background publications Anderson, Anderson: "TIM-3 in autoimmunity." in: Current opinion in immunology, Vol. 18, Issue 6, pp. 665-9, 2006 (PubMed).

Anderson, Anderson: "TIM-3 in autoimmunity." in: Current opinion in immunology, Vol. 18, Issue 6, pp. 665-9, 2006 (PubMed).

Sánchez-Fueyo, Tian, Picarella, Domenig, Zheng, Sabatos, Manlongat, Bender, Kamradt, Kuchroo, Gutiérrez-Ramos, Coyle, Strom: "Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance." in: Nature immunology, Vol. 4, Issue 11, pp. 1093-101, 2003 (PubMed).

Sabatos, Chakravarti, Cha, Schubart, Sánchez-Fueyo, Zheng, Coyle, Strom, Freeman, Kuchroo: "Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance." in: Nature immunology, Vol. 4, Issue 11, pp. 1102-10, 2003 (PubMed).

Sánchez-Fueyo, Tian, Picarella, Domenig, Zheng, Sabatos, Manlongat, Bender, Kamradt, Kuchroo, Gutiérrez-Ramos, Coyle, Strom: "Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance." in: Nature immunology, Vol. 4, Issue 11, pp. 1093-101, 2003 (PubMed).

Sabatos, Chakravarti, Cha, Schubart, Sánchez-Fueyo, Zheng, Coyle, Strom, Freeman, Kuchroo: "Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance." in: Nature immunology, Vol. 4, Issue 11, pp. 1102-10, 2003 (PubMed).

Munder, Bettelli, Monney, Slavik, Nicholson, Kuchroo: "Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand." in: The Journal of experimental medicine, Vol. 196, Issue 9, pp. 1151-62, 2002 (PubMed).

Monney, Sabatos, Gaglia, Ryu, Waldner, Chernova, Manning, Greenfield, Coyle, Sobel, Freeman, Kuchroo: "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease." in: Nature, Vol. 415, Issue 6871, pp. 536-41, 2002 (PubMed).

Monney, Sabatos, Gaglia, Ryu, Waldner, Chernova, Manning, Greenfield, Coyle, Sobel, Freeman, Kuchroo: "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease." in: Nature, Vol. 415, Issue 6871, pp. 536-41, 2002 (PubMed).

Munder, Bettelli, Monney, Slavik, Nicholson, Kuchroo: "Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand." in: The Journal of experimental medicine, Vol. 196, Issue 9, pp. 1151-62, 2002 (PubMed).