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  • 产品名称：CytotoxicT-Lymphocyte-AssociatedProtein4(CTLA4)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CytotoxicT-Lymphocyte-AssociatedProtein4(CTLA4)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
Molecular Weight 15.9 kDa
NCBI Accession NP_033973
UniProt P09793
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
Binding Studies (Bind) image for Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (Active) protein (His tag) (ABIN2870729) Immobilized Mouse B7-1, Fc Tag (Cat# CD0-M5259) at 2 μg/mL (100 µl/well),can bind Mou...
Binding Studies (Bind) image for Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (Active) protein (His tag) (ABIN2870729) Immobilized Mouse B7-2, Fc Tag (Cat# CD6-M5251) at 5 μg/mL (100 µl/well),can bind Mou...
SDS-PAGE (SDS) image for Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (Active) protein (His tag) (ABIN2870729) Mouse CTLA-4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained o...