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  • 产品名称：ICOS(Active)protein(FcTag)

  • 产品型号：
  • 产品厂商：ACROBiosystems
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简单介绍：
ICOS(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity 50 % human ICOS (Fc Tag) and 50 % human IgG1 Fc.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Molecular Weight 40.4 kDa
NCBI Accession NP_036224
UniProt Q9Y6W8
Research Area Immunology, Adaptive Immunity, CD Antigens, Inflammation
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for ICOS (Active) protein (Fc Tag) (ABIN2870647) Human ICOS, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained over...
Binding Studies (Bind) image for ICOS (Active) protein (Fc Tag) (ABIN2870647) Immobilized Human B7-H2, His Tag (Cat# B72-H5221) at 1 μg/mL (100 µl/well),can bind H...