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  • 产品名称：GDNFFamilyReceptoralpha2(GFRA2)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
GDNFFamilyReceptoralpha2(GFRA2)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 47.6 kDa. The protein migrates as 60-70 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >97 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Neurturin at 1 μg/mL can bind rhGFRA2 with an apparent KD < 8 nM.
Background GDNF family receptor alpha-2 (GFRA2) is also known as GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, is a cell membrane protein which belongs to the GDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-beta superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. The isoform 1 of GFRA2 is found in both brain and placenta. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor and also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor.
Molecular Weight 47.6 kDa
NCBI Accession NP_001486
UniProt O00451
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
Supplier Images
SDS-PAGE (SDS) image for GDNF Family Receptor alpha 2 (GFRA2) (Active) protein (His tag) (ABIN2444130) Human GFR alpha-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stai...