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  • 产品名称：TCellImmunoreceptorwithIgandITIMDomains(TIGIT)(AA16-142)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
TCellImmunoreceptorwithIgandITIMDomains(TIGIT)(AA16-142)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. As a result of glycosylation, the protein migrates as 45-50 kDa under reducing (R) condition, and 90-116 kDa under non-reducing (NR) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Molecular Weight 40.4 kDa
UniProt G1SLC1
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 16-142) (Active) protein (Fc Tag) (ABIN4949203) Rabbit TIGIT, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. ...