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  • 产品名称：AminoacyltRNASynthetaseComplex-InteractingMultifunctionalProtein1(AIMP1)(AA2-31

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  • 产品厂商：ACROBiosystems
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简单介绍：
AminoacyltRNASynthetaseComplex-InteractingMultifunctionalProtein1(AIMP1)(AA2-312)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 35.2 kDa. The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is also known as multisynthase complex auxiliary component p43 and endothelial monocyte-activating polypeptide II (EMAP-II). AIMP1 is a cytokine that may be induced by apoptosis and is also released from professional antigen-presenting cells such as dendritic cells. The release of AIMP1 renders the tumor-associated vasculature sensitive to tumor necrosis factor. Furthermore, AIMP1 binds tRNA and stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. This protein possesses inflammatory cytokine activity. Also, AIMP1 negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.
Molecular Weight 35.2 kDa
NCBI Accession NP_004748
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1) (AA 2-312) (Active) protein (His tag) (ABIN4949072) Human AIMP1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...