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  • 产品名称：FK506BindingProtein4,59kDa(FKBP4)(AA1-459)(Active)protein(PAtag,Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
FK506BindingProtein4,59kDa(FKBP4)(AA1-459)(Active)protein(PAtag,Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus, followed by a PA tag, and has a calculated MW of 55.1 kDa. The predicted N-terminus is Met 1. The reducing (R) protein migrates as 60 kDa in SDS-PAGE.
Purity >90 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) is also known as immunophilin FKBP52. FKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP4 has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. FKBP4 interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes.
Molecular Weight 55.1 kDa
UniProt Q02790
Research Area Heat Shock Proteins, Metabolism
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for FK506 Binding Protein 4, 59kDa (FKBP4) (AA 1-459) (Active) protein (PA tag,His tag) (ABIN4949097) Human FKBP4, His Tag & PA Tag on SDS-PAGE under reducing (R) condition. The gel was s...