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  • 产品名称：PoliovirusReceptor-Related3(PVRL3)(AA58-400)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
PoliovirusReceptor-Related3(PVRL3)(AA58-400)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.3 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6, MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
Molecular Weight 64.3 kDa
NCBI Accession NP_056295
UniProt Q9NQS3
Pathways Cell-Cell Junction Organization
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Poliovirus Receptor-Related 3 (PVRL3) (AA 58-400) (Active) protein (Fc Tag) (ABIN4949138) Human Nectin-3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Binding Studies (Bind) image for Poliovirus Receptor-Related 3 (PVRL3) (AA 58-400) (Active) protein (Fc Tag) (ABIN4949138) Immobilized Human CD113, Fc Tag (Cat# PV3-H5255) at 10 μg/mL (100 μL/well) can bind B...