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  • 产品名称：Interleukin23Receptor(IL23R)(AA24-372)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interleukin23Receptor(IL23R)(AA24-372)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 66.8 kDa. As a result of glycosylation, the protein migrates as 90-100 kDa under reducing (R) condition, and 180-200 kDa under non-reducing (NR) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Molecular Weight 66.8 kDa
NCBI Accession NP_653131
UniProt Q8K4B4
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Interleukin 23 Receptor (IL23R) (AA 24-372) (Active) protein (Fc Tag) (ABIN4949177) Mouse IL-23 R, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions....